Double-Blind, Placebo-Controlled Study of Pyridostigmine in Postural Tachycardia Syndrome
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 2
SUMMARY
This is a 3-day study comparing pyridostigmine versus placebo in the treatment of postural tachycardia syndrome (POTS). The researchers expect pyridostigmine to improve tachycardia and stabilize blood pressure.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 15
Maximum Age: 55
Healthy Volunteers: f
View:
⁃ Diagnosis of postural tachycardia syndrome using the following criteria:
• Orthostatic heart rate increment greater than or equal to 30 beats per minute (bpm) within 5 minutes of head-up tilt.
• Symptoms of orthostatic intolerance. These include weakness, lightheadedness, blurred vision, nausea, palpitations, and difficulty with concentration and thinking.
⁃ Both criteria must be fulfilled.
Locations
United States
Minnesota
Mayo Clinic
RECRUITING
Rochester
Time Frame
Start Date: 2006-10
Estimated Completion Date: 2026-02
Participants
Target number of participants: 50
Treatments
Active_comparator: pyridostigmine
Active study drug
Placebo_comparator: Placebo
Control
Authors
Related Therapeutic Areas
Sponsors
Leads: Mayo Clinic
Collaborators: National Institute of Neurological Disorders and Stroke (NINDS)